Publication

Dysregulated Urinary Arginine Metabolism in Older Adults With Amnestic Mild Cognitive Impairment

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Last modified
  • 05/22/2025
Type of Material
Authors
    Yue-Qi Zhang, Shanghai Jiao Tong UniversityYa-Bin Tang, Shanghai Jiao Tong UniversityEric Dammer, Emory UniversityJian-Ren Liu, Shanghai Jiao Tong UniversityYu-Wu Zhao, Shanghai Jiao Tong UniversityLiang Zhu, Shanghai Jiao Tong UniversityRu-Jing Ren, Shanghai Jiao Tong UniversityHong-Zhuan Chen, Shanghai Jiao Tong UniversityGang Wang, Shanghai Jiao Tong UniversityQi Cheng, Shanghai Jiao Tong University
Language
  • English
Date
  • 2019-04-24
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2019 Zhang, Tang, Dammer, Liu, Zhao, Zhu, Ren, Chen, Wang and Cheng.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1663-4365
Volume
  • 11
Start Page
  • 90
End Page
  • 90
Grant/Funding Information
  • This study was supported by funds from Foundation of Collaborative Research Center for translational medicine; Shanghai Jiao Tong University School of Medicine (2015272); Natural Science Foundation of China (81371218, 81671043); a Clinical research project through Shanghai Jiao Tong University School of Medicine (No. DLY201614); and from the Shuguang Program (16SG15) supported by Shanghai Education Development Foundation; and Gaofeng Clinical Medicine Grant (20172001) supported by the Shanghai Municipal Education Commission.
Supplemental Material (URL)
Abstract
  • Background: Urine samples, which capture an individual's metabolic profile, are ideal for the exploration of non-invasive biomarkers to confirm the amnestic mild cognitive impairment (aMCI) status of patients vs. unimpaired ones. Objective: We aimed to detect differentially metabolized amino acids, which are important objectives in metabolomics, garnering particular attention in biomedical pathogenesis from the urine of aMCI patients, which may give clinicians the possibility to intervene with early treatments that curb Alzheimer's disease (AD). Methods: The study included 208 subjects, 98 of whom were aMCI patients, and 110 who were control subjects without dementia. Urine samples were taken from each participant and supernatant was obtained for analysis. The concentrations of amino acids were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: Urinary arginine levels in aMCI patients are obviously lower than in normal controls (q < 0.2 and p < 0.05). Meanwhile, aMCI patients had significant reduced urinary global arginine bioavailability ratio (GABR), and GABR in urine displayed a positive correlation with the score of CMMSE. Conclusion: Urinary dysregulated arginine metabolism that may serve as a helpful clinical diagnostic biomarker for aMCI in older adults.
Author Notes
Keywords
Research Categories
  • Chemistry, Biochemistry
  • Health Sciences, Medicine and Surgery
  • Biology, Neuroscience

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