ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease

• Type of Material: Article
• Authors: Dong Hun Lee, Emory University; Tae Min Kim, Seoul National University; Joo Kyung Kim, Emory University; Changwon Park, Emory University
• Language: English
• Date: 2019-01-01
• Publisher: Ivyspring International Publisher
• Publication Version: Final Published Version
• Copyright Statement: © The author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.7150/thno.35300
• Title of Journal or Parent Work: Theranostics
• Volume: 9
• Issue: 19
• Start Page: 5694
• End Page: 5705
• Grant/Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1A02085481) (T.M.K), and National Institutes of Health (NIH) R01 HL119291 (to C.P.), Children's Miracle Network 660085-1116 (to C.P.) and Children's Heart Research and Outcomes Center and Children's Healthcare of Atlanta 00060337 (to C.P.).
• Keywords: Life Sciences & Biomedicine; GENE-TRANSFER; cardiovascular; Science & Technology; FUNCTIONAL-NEURONS; angiogenesis; CARDIAC LYMPHATIC OBSTRUCTION; EXTRACELLULAR VESICLES; MASTER REGULATOR; DIRECT CONVERSION; VASCULAR REGENERATION; ER71/ETV2; direct cell reprogramming; Medicine, Research & Experimental; Research & Experimental Medicine; ADULT HUMAN FIBROBLASTS; MYOCARDIAL-INFARCTION; FLK1/VEGFR2; ENDOTHELIAL-CELLS
• Research Categories: Health Sciences, Pharmacology; Chemistry, Biochemistry

Abstract

Cardiovascular diseases have long been the leading cause of mortality and morbidity in the United States as well as worldwide. Despite numerous efforts over the past few decades, the number of the patients with cardiovascular disease still remains high, thereby necessitating the development of novel therapeutic strategies equipped with a better understanding of the biology of the cardiovascular system. Recently, the ETS transcription factor, ETV2 (also known as ER71), has been recognized as a master regulator of the development of the cardiovascular system and plays an important role in pathophysiological angiogenesis and the endothelial cell reprogramming. Here, we discuss the detailed mechanisms underlying ETV2/ER71-regulated cardiovascular lineage development. In addition, recent reports on the novel functions of ETV2/ER71 in neovascularization and direct cell reprogramming are discussed with a focus on its therapeutic potential for cardiovascular diseases.