Membranous nephropathy associated with gastrointestinal stromal tumour: A case report

• Type of Material: Article
• Authors: Adela Cimic, Emory University; Stephen Pastan, Emory University; Vanesa Bijol, Emory University
• Language: English
• Date: 2009-08-01
• Publisher: Oxford University Press (OUP): Policy B
• Publication Version: Final Published Version
• Copyright Statement: © The Author [2009] .
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1093/ndtplus/sfp028
• Title of Journal or Parent Work: NDT Plus
• ISSN: 1753-0784
• Volume: 2
• Issue: 4
• Start Page: 306
• End Page: 308
• Grant/Funding Information: A.C.'s work has been made possible through her ISN-funded fellowship.
• Keywords: proteinuria; GIST; membranous nephropathy
• Research Categories: Health Sciences, Pathology

Abstract

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN 1. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature.