Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

• Type of Material: Article
• Authors: Hamed Ekhtiari, Laureate Institute for Brain Research; Hosna Tavakoli, Institute for Cognitive Science Studies; Giovanni Addolorato, Catholic University of Rome; Chris Baeken, University Hospital Ghent; Antonello Bonci, National Institute on Drug Abuse; Salvatore Campanella, Université Libre de Bruxelles; Luis Castelo-Branco, Harvard University; Gaelle Challet-Bouju, Nantes Universite; William McDonald, Emory University; Justine Welsh, Emory University
• Language: English
• Date: 2019-09-01
• Publisher: Pergamon-Elsevier Science Ltd.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.neubiorev.2019.06.007
• Title of Journal or Parent Work: Neuroscience and Biobehavioral Review
• Volume: 104
• Start Page: 118
• End Page: 140
• Grant/Funding Information: Michael A. Nitsche receives funding from the German Research Foundation (DFG; SFB 1280 Project A6), and the German Federal Ministry of Education and Research (BMBF, GCBS grant 01EE1403C).; Xavier Noël is supported by a grant of the Belgian Fund for Scientific Research (grant PDR/OL T.0146.18).; Shirley Fecteau is supported by the Canada Research Chair in Cognitive Neuroplasticity. Stacey Daughters is supported by the NIH/NIDA (R01DA026424).; Elliot Stein and Vaughn Steele are supported by the Intramural Research Program of the National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, Maryland and The Center on Compulsive Behavior. Antonio Verdejo-García is supported by Australian Medical Research Future Fund (MRF1141214).; Vincent Van Waes is supported by the Fondation pour la Recherche en Alcoologie (FRA) and the Région Bourgogne Franche-Comté.; Ganesan Venkatasubramanian is supported by the Swarnajayanti Fellowship Grant (DST/SJF/LSA-02/2014–15) by the Department of Science and Technology, Government of India.; Coleen A. Hanlon received funding from the NIDA (R01DA04447) and NIAAA (P50AA010761).; Anna E. Goudriaan and Renée S. Schluter are funded by an innovative VIDI grant awarded to AG (grant number 91713354) by the Netherlands Health Research Organization (ZonMW).; Laurie Zawertailo received funding from Canadian Institutes of Health Research, Canadian Cancer Society, Ontario Ministry of Health, and Global Research Awards in Nicotine Dependence. Flavio Frohlich received funding from NIH, Bran and Behavior Research Foundation, Human Frontiers Science Program, Tal Medical, and the Neurocare Group.; Michael J. Wesley receives funding from the NIDA (K01DA043652; R01DA045023 and R01DA047368).
• Keywords: Go-Nogo task; Noninvasive brain stimulation; Addiction; Behavioral Sciences; Neurosciences & Neurology; Transcranial magnetic stimulation; tDCS; Transcranial electrical stimulation; Dorsolateral prefrontal cortex; Non-invasive brain stimulation; Substance use disorder; Psychiatry; Neurosciences; Alcohol dependent moments; Compulsive drug use; Life Sciences & Biomedicine; Human motor cortex; Major depressive disorder; Theta burst stimulation; Science & Technology; Functional connectivity; tES; NIBS; rTMS
• Research Categories: Psychology, Cognitive; Biology, Neuroscience; Psychology, Behavioral

Abstract

There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.