Publication

Solenoidal Micromagnetic Stimulation Enables Activation o Axons With Specific Orientation

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Last modified
  • 05/15/2025
Type of Material
Authors
    Laleh Golestanirad, Massachusetts General HospitalJohn T. Gale, Emory UniversityNauman F. Manzoor, Cleveland Clinic Lerner Research InstituteHyun-Joo Park, Cleveland Clinic Lerner Research InstituteLyall Glait, Cleveland Clinic Lerner Research InstituteFrederick Haer, Frederick Haer CorporationJames A. Kaltenbach, Cleveland Clinic Lerner Research InstituteGiorgio Bonmassar, Massachusetts General Hospital
Language
  • English
Date
  • 2018-07-27
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2018 Golestanirad, Gale, Manzoor, Park, Glait, Haer, Kaltenbach and Bonmassar.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-042X
Volume
  • 9
Issue
  • JUL
Start Page
  • 724
End Page
  • 724
Grant/Funding Information
  • This work was supported by the US National Institutes of Health (NIH) grants R43MH107037 (FH, JG, GB, and JK), R01MH111875 (GB), and K99EB021320 (LaG).
Abstract
  • Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations. One of the most remarkable properties is that μMS is theoretically capable of activating neurons with specific axonal orientations. Here, we used computational electromagnetic models of the μMS coils adjacent to neuronal tissue combined with axon cable models to investigate μMS orientation-specific properties. We found a 20-fold reduction in the stimulation threshold of the preferred axonal orientation compared to the orthogonal direction. We also studied the directional specificity of μMS coils by recording the responses evoked in the inferior colliculus of rodents when a pulsed magnetic stimulus was applied to the surface of the dorsal cochlear nucleus. The results confirmed that the neuronal responses were highly sensitive to changes in the μMS coil orientation. Accordingly, our results suggest that μMS has the potential of stimulating target nuclei in the brain without affecting the surrounding white matter tracts.
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Keywords
Research Categories
  • Health Sciences, Medicine and Surgery
  • Biology, Physiology
  • Biology, Neuroscience

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