Transfusion-related Gut Injury and Necrotizing Enterocolitis

• Type of Material: Article
• Authors: Allison Rose, Emory University; Vivek Saroha, Emory University; Ravi Patel, Emory University
• Language: English
• Date: 2020-06-01
• Publisher: W B SAUNDERS CO-ELSEVIER INC
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.clp.2020.02.002
• Title of Journal or Parent Work: CLINICS IN PERINATOLOGY
• Volume: 47
• Issue: 2
• Start Page: 399
• End Page: +
• Keywords: Feeding; BIRTH-WEIGHT INFANTS; THRESHOLDS; CONSUMPTION; ANEMIA; Life Sciences & Biomedicine; NEAR-INFRARED SPECTROSCOPY; BLOOD-CELL TRANSFUSIONS; Transfusion; ASSOCIATION; Morbidity; SPLANCHNIC TISSUE OXYGENATION; PREMATURE-INFANTS; Obstetrics & Gynecology; PRETERM INFANTS; Pediatrics; Science & Technology; Anemia; Preterm

Abstract

Necrotizing enterocolitis (NEC) accounts for 10% of deaths in neonatal intensive care units. Several causal mechanisms are likely to lead to a final common disease phenotype. This article summarizes recent data on NEC following red blood cell (RBC) transfusion, with a focus on the most recent literature and ongoing trials. It highlights potential mechanisms from preclinical and human physiologic studies. It also discusses the role of feeding during RBC transfusion and the risk of NEC. Ongoing randomized trials will provide important data on how liberal or conservative approaches to RBC transfusion influence the risk of NEC.