Amyloid by default

• Type of Material: Article
• Authors: Lary C Walker, Emory University; Mathias Jucker, University of Tübingen
• Language: English
• Date: 2011-06
• Publisher: Springer Nature
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2011, Springer Nature America, Inc.
• Final Published Version (URL): https://doi.org/10.1038/nn.2853
• Title of Journal or Parent Work: Nature Neuroscience
• Volume: 14
• Issue: 6
• Start Page: 669
• End Page: 670
• Keywords: transgenic mice; sustained metabolic activation; default-mode network; Alzheimer’s disease
• Research Categories: Biology, Molecular; Biology, Neuroscience

Abstract

The sustained metabolic activation of the brain’s default-mode network is thought to render the system vulnerable to Alzheimer’s disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.