mRNA localization: an orchestration of assembly, traffic and synthesis

• Type of Material: Article
• Authors: Lei Xing, Emory University; Gary Bassell, Emory University
• Language: English
• Date: 2013-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 John Wiley & Sons A/S
• Final Published Version (URL): http://onlinelibrary.wiley.com/doi/10.1111/tra.12004/abstract
• Title of Journal or Parent Work: Traffic
• ISSN: 1398-9219
• Volume: 14
• Issue: 1
• Start Page: 2
• End Page: 14
• Grant/Funding Information: This work was supported by funding from NIH (to GB).
• Keywords: mRNA transport; RNA binding protein; molecular motor; myosin; mRNA localization; cytoskeleton; RNA granule; kinesin; dynein
• Research Categories: Biology, Cell; Biology, Neuroscience

Abstract

Asymmetrical mRNA localization and subsequent local translation provide efficient mechanisms for protein sorting in polarized cells. Defects in mRNA localization have been linked to developmental abnormalities and neurological diseases. Thus, it is critical to understand the machineries mediating and mechanisms underlying the asymmetrical distribution of mRNA and its regulation. The goal of this review is to summarize recent advances in the understanding of mRNA transport and localization, including the assembly and sorting of transport mRNP granules, molecular mechanisms of active mRNP transport, cytoskeletal interactions and regulation of these events by extracellular signals.