Glycans and the platelet life cycle

• Type of Material: Article
• Authors: Renhao Li, Emory University; Karin M. Hoffmeister, Brigham and Women's Hospital; Herve Falet, Brigham and Women's Hospital
• Language: English
• Date: 2016-09-01
• Publisher: Taylor & Francis: STM, Behavioural Science and Public Health Titles
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 Taylor & Francis.
• Final Published Version (URL): http://dx.doi.org/10.3109/09537104.2016.1171304
• Title of Journal or Parent Work: Platelets
• ISSN: 0953-7104
• Volume: 27
• Issue: 6
• Start Page: 505
• End Page: 511
• Grant/Funding Information: This work was supported by National Institutes of Health (NIH) grants HL107146, HL089224. (to K.M.H.) and HL082808, HL123984 (to R.L.); and bridge grants from the Brigham Research Institute and the American Society of Hematology (to H.F.).
• Keywords: GLYCOPROTEIN-IB-ALPHA; LECTIN DOMAIN; VON-WILLEBRAND-FACTOR; CHILLED BLOOD-PLATELETS; Life Sciences & Biomedicine; A1 DOMAIN; THROMBOTIC THROMBOCYTOPENIA; VONWILLEBRAND-FACTOR; Science & Technology; ASHWELL-MORELL RECEPTOR; GPIb; Cell Biology; sialic acid; Hematology; Ashwell-Morell receptor; platelet clearance; IMMUNE THROMBOCYTOPENIC PURPURA; BERNARD-SOULIER-SYNDROME
• Research Categories: Health Sciences, General

Abstract

Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.