Publication

A plague of actin disassembly

Downloadable Content

Persistent URL
Last modified
  • 03/03/2025
Type of Material
Authors
    Shoichiro Ono, Emory University
Language
  • English
Date
  • 2017-05-12
Publisher
  • American Society for Biochemistry and Molecular Biology
Publication Version
Copyright Statement
  • This research was originally published © the American Society for Biochemistry and Molecular Biology
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 0021-9258
Volume
  • 292
Issue
  • 19
Start Page
  • 8101
End Page
  • 8102
Grant/Funding Information
  • Supported in part by National Institutes of Health Grant R01AR048615.
Abstract
  • Pathogenic Yersinia species employ several strategies to evade the host immune system, including interfering with cytoskeletal remodeling as a way to block macrophage phagocytosis. The kinase YopO binds directly to monomeric actin and phosphorylates the actin-remodeling protein gelsolin, but the functional importance of this gelsolin modification has not been clear. A combined biochemical, computational, and biophysical study now reveals that YopO-mediated phosphorylation activates host gelsolin, leading to severed actin filaments and disturbed actin dynamics.
Author Notes
  • To whom correspondence should be addressed: Dept. of Pathology, Emory University, 615 Michael St., Whitehead Research Bldg., Rm. 105N, Atlanta, GA 30322. E-mail: sono@emory.edu.
Research Categories
  • Health Sciences, Pathology
  • Biology, Cell

Tools

Relations

In Collection:

Items

Thumbnail Title File Description Date Uploaded Visibility Actions
file details Publication File - s2s4v.pdf Primary Content 2025-02-28 Public Download