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Natural and Synthetic Sialylated Glycan Microarrays and Their Applications

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Last modified
  • 05/15/2025
Type of Material
Authors
    Alyssa M. McQuillan, Beth Israel Deaconess Medical CenterLauren Byrd-Leotis, Beth Israel Deaconess Medical CenterJamie Heimburg-Molinaro, Beth Israel Deaconess Medical CenterRichard Cummings, Emory University
Language
  • English
Date
  • 2019-09-13
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © Copyright © 2019 McQuillan, Byrd-Leotis, Heimburg-Molinaro and Cummings.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2296-889X
Volume
  • 6
Grant/Funding Information
  • This work was supported by NIH Grant No. P41GM103694; and US Department of Health and Human Services Grant No. HHSN272201400004C.
Abstract
  • This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated compounds, highlighting N-glycolyl (Gc) modified sialylated compounds. A brief discussion of binding interactions by lectins, antibodies, and viruses, and their relevance that have been observed with sialylated glycan microarrays is presented, as well as a discussion of cross-comparisons of array platforms and efforts to centralize and standardize the glycan microarray data.
Author Notes
Keywords
Research Categories
  • Biology, Molecular
  • Chemistry, Biochemistry
  • Health Sciences, Immunology

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