Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

• Type of Material: Article
• Authors: Katherine Immergluck, Emory University; Mark D. Gonzalez, Emory University; Jennifer Frediani, Emory University; Joshua Levy, Emory University; Janet Figueroa, Emory University; Anna Wood, Emory University; Beverly Rogers, Emory University; Jared O'Neal, Emory University; Roger Elias-Marcellin, Emory University; Allie Suessmith, Emory University; Julie Sullivan, Emory University; Raymond Schinazi, Emory University; Ahmed Babiker, Emory University; Anne Piantadosi, Emory University; Miriam Vos, Emory University; Gregory Martin, Emory University; Wilbur A. Lam, Emory University; Jesse Waggoner, Emory University
• Language: English
• Date: 2021-11-01
• Publisher: CENTERS DISEASE CONTROL & PREVENTION
• Publication Version: Final Published Version
• Copyright Statement: This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
• Final Published Version (URL): http://dx.doi.org/10.3201/eid2711.211135
• Title of Journal or Parent Work: EMERGING INFECTIOUS DISEASES
• Volume: 27
• Issue: 11
• Start Page: 2887
• End Page: 2891
• Grant/Funding Information: This study was supported by the National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering (grants U54 EB027690 02S1 and UL1 TR002378).
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; Infectious Diseases
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Immunology

Abstract

Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from antigennegative persons. Subgenomic RNA in midturbinate swab specimens might be useful for routine diagnostics to identify active virus replication.