Characterizing the heterogeneity of globus pallidus neuron behavior by comparing a real neuron database with model databases of varying conductance parameters

• Type of Material: Article
• Authors: Cengiz Gunay, Emory University; Jeremy R Edgerton, Emory University; Dieter Jaeger, Emory University
• Language: English
• Date: 2007
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: © 2007 Günay et al
• License: Creative Commons Attribution 2.0 Generic
• Final Published Version (URL): http://dx.doi.org/10.1186/1471-2202-8-S2-P123
• Title of Journal or Parent Work: BMC Neuroscience
• ISSN: 1471-2202
• Volume: 8
• Issue: Suppl 2
• Start Page: P123
• End Page: P123

Abstract

The function of brain networks is highly dependent on the dynamical properties of single neurons, whose activity ranges from complex spontaneous activity patterns such as oscillations and bursting, to a variety of synaptic response patterns serving functions such as coincidence detection or rebound firing. These dynamical properties vary in time through modulation and plasticity, and are also heterogeneous across individual neurons of the same type. Commonly, neurons show two to five-fold variability in the density of voltage-gated conductances, which accounts for large variations in dynamical behavior.