Indole derivatives, microbiome and graft versus host disease

• Type of Material: Article
• Authors: Muna Qayed, Emory University; David Michonneau, Saint Louis Hospital, France; Gerard Socie, Saint Louis Hospital, France; Edmund Waller, Emory University
• Language: English
• Date: 2021-06-01
• Publisher: CURRENT BIOLOGY LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.coi.2021.02.006
• Title of Journal or Parent Work: CURRENT OPINION IN IMMUNOLOGY
• Volume: 70
• Start Page: 40
• End Page: 47
• Grant/Funding Information: National Institutes of Health, Bethesda, MD (1R01CA188523-01A1).
• Keywords: TRYPTOPHAN-METABOLISM; Life Sciences & Biomedicine; T-CELLS; 2,3-DIOXYGENASE; AHR; INTESTINAL MICROBIOTA; Science & Technology; GUT MICROBIOME; TRANSPLANTATION; STEM-CELL; Immunology; ARYL-HYDROCARBON RECEPTOR; IMMUNITY

Abstract

Graft versus host disease is a life-threatening complication following allogeneic hematopoietic stem cell transplantation driven by donor T cells reacting against disparate host antigens. Immune homeostasis within the gut plays a major role in the graft versus host response. Gut microbiota and its metabolites impact gut integrity, inflammation and immune activation within the gut. This review will focus on the role of indoles, a product of microbiota metabolism, on gut homeostasis and our current understanding on how that modulates graft versus host disease.