COVID-19 and Down syndrome: the spark in the fuel

• Type of Material: Article
• Authors: Manini Majithia, Emory University; Susan P Ribeiro, Emory University
• Language: English
• Date: 2022-06-07
• Publisher: Nature Research (part of Springer Nature)
• Publication Version: Final Published Version
• Copyright Statement: © Springer Nature Limited 2022
• Final Published Version (URL): http://dx.doi.org/10.1038/s41577-022-00745-w
• Title of Journal or Parent Work: NATURE REVIEWS IMMUNOLOGY
• Volume: 22
• Issue: 7
• Start Page: 404
• End Page: 405
• Keywords: Infectious diseases; Immunopathogenesis
• Research Categories: Health Sciences, Pathology

Abstract

In individuals with Down syndrome, immune dysregulation is partially caused by chromosome 21 trisomy. Here, we discuss how these immune differences may result in poorer COVID-19 outcomes, including diminished responses to vaccination and possibly elevated risk for long COVID.