Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

• Type of Material: Article
• Authors: Sasapin G. Prakalapakorn, Emory University; C. Robert Bernardino, Yale University; Paul L. Auclair, Maine Medical Center; Hans Grossniklaus, Emory University
• Language: English
• Date: 2008-11
• Publisher: Springer Verlag (Germany)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ophtha.2008.04.037
• Title of Journal or Parent Work: Ophthalmologe
• ISSN: 0941-293X
• Volume: 115
• Issue: 11
• Start Page: 2065
• End Page: 2070
• Grant/Funding Information: Dr Grossniklaus is a recipient of the Research to Prevent Blindness Senior Scientific Investigator Award.; Supported in part by an unrestricted grant from Research to Prevent Blindness Inc, and National Institutes of Health P30 EY06360.
• Research Categories: Health Sciences, Opthamology; Health Sciences, Pathology

Abstract

Objective: To report the clinicopathologic features of 2 patients with carcinosarcoma of the orbit. Design: Case reports. Participants: Two patients with orbital carcinosarcoma were identified. Methods: Retrospective chart review with clinicopathologic correlation and literature review. Main Outcome Measures: Clinical examination, imaging studies, and histopathologic findings. Results: Two patients, a 56-year-old woman and a 91-year-old woman, with orbital carcinosarcoma were identified. Both tumors contained sarcomatous and carcinomatous components and invaded periorbital structures. Conclusions: Carcinosarcoma may arise in the orbit or extend into the orbit from the paranasal sinuses. This malignant neoplasm should be aggressively treated with a combination of surgical resection, chemotherapy, and radiation therapy.