Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation

• Type of Material: Article
• Authors: Hengte Ke, Harbin Institute of Technology; Jinrui Wang, Peking University; Sheng Tong, Georgia Institute of Technology; Yushen Jin, Harbin Institute of Technology; Shumin Wang, Peking University; Enze Qu, Peking University; Gang Bao, Emory University; Zhifei Dai, Peking University
• Language: English
• Date: 2014-01-01
• Publisher: IVYSPRING INT PUBL
• Publication Version: Final Published Version
• Copyright Statement: © Ivyspring International Publisher.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.7150/thno.7275
• Title of Journal or Parent Work: THERANOSTICS
• Volume: 4
• Issue: 1
• Start Page: 12
• End Page: 23
• Grant/Funding Information: This work was financially supported by National Natural Science Foundation for Distinguished Young Scholars (No. 81225011), State Key Program of National Natural Science of China (Grant No. 81230036) and National Natural Science Foundation of China (No. 21273014).
• Keywords: Photothermal therapy; THERAPY; IRON-OXIDE NANOPARTICLES; Superparamagnetic iron oxide nanoparticles; Medicine, Research & Experimental; Liquid perfluorocarbon nanocapules; IN-VIVO; AGENT; Life Sciences & Biomedicine; Gold nanoshell; Research & Experimental Medicine; MRI; Bimodal imaging; MACROPHAGE ENDOCYTOSIS; Science & Technology
• Research Categories: Biology, Molecular; Engineering, Biomedical

Abstract

Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.