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Editorial: The Role of Calcium Channels in Human Health and Disease

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Last modified
  • 05/14/2025
Type of Material
Authors
    Peng Zhang, Institute of ENTChang-Bo Zheng, Kunming Medical UniversityZhen Chen, Emory UniversityXiao-Yu Liu, Southern University of Science & Technology
Language
  • English
Date
  • 2022-01-21
Publisher
  • Frontiers Media SA
Publication Version
Copyright Statement
  • © 2022 Zhang, Zheng, Chen and Liu.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 9
Start Page
  • 834108
End Page
  • 834108
Grant/Funding Information
  • The present study was supported in part by the National Natural Science Foundation of China (82003108);
  • Guangdong Basic and Applied Basic Research Foundation (2021A1515010970);
  • Shenzhen Innovation of Science and Technology Commission (No. JCYJ20210324132407019,
  • LGKCYLWS2020095, LGKCYLWS2020099); Shenzhen Key Medical Discipline Construction Fund (No. SZXK039).
Abstract
  • Calcium is one of the most common signaling molecules in cells and is involved in regulating almost all biological functions. Calcium can regulate molecular events such as gene expression and regulation, protein phosphorylation and modification; cellular activities including energy metabolism, cell division, proliferation, differentiation, and apoptosis; tissue level functions such as embryo formation and development, heart and muscle contraction, neuronal communication, learning and memory (Berridge et al., 2000; Clapham, 2007). Therefore, it is not surprising that imbalance in intracellular calcium homeostasis can lead to severe pathological disorders including cardiovascular disease and tumor (Liu et al., 2019). Calcium channels mediate the movement of calcium ions into the cytoplasm and organelles, and are important regulators of calcium homeostasis. Thus, understanding the regulatory mechanism of calcium channels is an important step towards revealing the rules that govern calcium homeostasis and life processes. This special Research Topic highlights eight studies on novel roles of calcium channels in pathophysiological processes.
Author Notes
Keywords
Research Categories
  • Health Sciences, Public Health
  • Chemistry, Biochemistry
  • Biology, Molecular

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