Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

• Type of Material: Article
• Authors: Narut Prasitlumkum, University of Riverside; Ronpichai Chokesuwattanaskul, Chulalongkorn University; Charat Thongprayoon, Mayo Clinic, Rochester; Tarun Bathini, University of Arizona, Tucson; Saraschandra Vallabhajosyula, Emory University; Wisit Cheungpasitporn, Mayo Clinic, Rochester
• Language: English
• Date: 2020-12-01
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2020 by the authors
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/diseases8040040
• Title of Journal or Parent Work: Diseases
• Volume: 8
• Issue: 4
• Grant/Funding Information: This research received no external funding.
• Keywords: myocardial injury; coronavirus; COVID-19; meta-analysis; systematic review
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Introduction: The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. Methods: We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. Results: We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I2 = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. Conclusion: The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing.