Sleep duration and biomarkers of inflammation in African American and white participants with a parental history of Alzheimer's disease

• Type of Material: Article
• Authors: Victoria Pak, Emory University; Sudeshna Paul, Emory University; Dominika Swieboda, Woodruff Health Sciences Center; Monique Balthazar, Emory University; Whitney Wharton, Emory University
• Language: English
• Date: 2022-01-01
• Publisher: Wiley Periodicals LLC
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/trc2.12332
• Title of Journal or Parent Work: Alzheimer's and Dementia: Translational Research and Clinical Interventions
• Volume: 8
• Issue: 1
• Start Page: e12332
• End Page: e12332
• Keywords: race; sleep; parental history; inflammation; cerebrospinal fluid; Alzheimer's disease; biomarker; cognition
• Research Categories: Health Sciences, Nursing

Abstract

Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race. Methods: Seventy-six cognitively normal, middle aged (45–65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed. Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), P =.000004). We found a statistically significant association between plasma IL-10 and sleep duration (Spearman's ρ = 0.26, P =.04) and CSF ICAM-1 and sleep quality (Spearman's ρ = 0.30, P =.03). Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.