Publication

Limited Neonatal Carbohydrate-Specific Antibody Repertoire Consecutive to Partial Prenatal Transfer of Maternal Antibodies

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Last modified
  • 05/15/2025
Type of Material
Authors
    Katharina Kappler, University of ZurichTanja Restin, University of ZurichYi Lasanajak, Emory UniversityDavid Smith, Emory UniversityDirk Bassler, University of ZurichThierry Hennet, University of Zurich
Language
  • English
Date
  • 2020-10-14
Publisher
  • Frontiers Media SA
Publication Version
Copyright Statement
  • © 2020 Kappler, Restin, Lasanajak, Smith, Bassler and Hennet.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 11
Start Page
  • 573629
End Page
  • 573629
Grant/Funding Information
  • This work was supported by the Swiss National Foundation grant 314730_172880 and by Novartis FreeNovation to TH and partially supported by the Emory Comprehensive Glycomics Core (ECGC), which is an Emory Integrated Core Facility subsidized by the Emory University School of Medicine.
Supplemental Material (URL)
Abstract
  • Despite the prominence of carbohydrate-specific antibodies in human sera, data on their emergence and antigen specificities are limited. Whereas maternal IgG are transferred prenatally to the fetal circulation, IgM present in cord blood originate from fetal B lymphocytes. Considering the limited exposure of the fetus to foreign antigens, we assessed the repertoire of carbohydrate-specific antibodies in human cord blood and matched maternal blood samples using glycan arrays. Carbohydrate-specific IgM was absent in cord blood, whereas low cord blood IgG reactivity to glycans was detectable. Comparing IgG reactivities of matched pairs, we observed a general lack of correlation in the antigen specificity of IgG from cord blood and maternal blood due to a selective exclusion of most carbohydrate-specific IgG from maternofetal transfer. Given the importance of intestinal bacteria in inducing carbohydrate-specific antibodies, we analyzed global antibody specificities toward commensal bacteria. Similar IgG reactivities to specific Bacteroides species were detected in matched cord and maternal blood samples, thus pointing to an efficient maternal transfer of anti-microbial IgG. Due to the observed selectivity in maternofetal IgG transfer, the lack of fetal antibodies to carbohydrate epitopes is only partially compensated by maternal IgG, thus resulting in a weak response to carbohydrate antigens in neonates.
Author Notes
Keywords
Research Categories
  • Biology, Physiology
  • Health Sciences, Immunology
  • Biology, Cell

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