The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen.

• Type of Material: Article
• Authors: Evan Kiely, Emory University; Melissa Gilbert-Ross, Emory University
• Language: English
• Date: 2021
• Publisher: microPublication Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2021 by the authors
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.17912/micropub.biology.000424
• Title of Journal or Parent Work: MicroPubl Biol
• Volume: 2021
• Grant/Funding Information: This work was supported by National Institutes of Health grant R01CA201340 to MGR
• Keywords: lethal allele; Deficiency
• Research Categories: Health Sciences, Oncology

Abstract

The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970's and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this work, the lethal allele E7.25D.7 was identified as being of phenotypic interest. Here we report the genetic mapping of E7.25D.7, an allele of the sterile-20 kinase misshapen (msn).