Healthy adolescent performance on the MATRICS Consensus Cognitive Battery (MCCB): Developmental data from two samples of volunteers

• Type of Material: Article
• Authors: William S. Stone, Harvard Medical School; Raquelle I. Mesholam-Gately, Harvard Medical School; Anthony J. Giuliano, Worcester Recovery Center and Hospital; Kristen A. Woodberry, Harvard Medical School; Jean Addington, University of Calgary; Carrie E. Bearden, University of California Los Angeles; Kristin S. Cadenhead, University of California Los Angeles; Tyrone D. Cannon, Yale University; Barbara A. Cornblatt, Zucker Hillside Hospital; Daniel H. Mathalon, University of California San Francisco; Thomas H. McGlashan, Yale University; Diana O. Perkins, University of North Carolina at Chapel Hill; Ming T. Tsuang, University of California San Diego; Elaine Walker, Emory University; Scott W. Woods, Yale University; Robert W. McCarley, Harvard Medical School at Brockton VA Medical Center; Robert Heinssen, National Institute of Mental Health; Michael F. Green, University of California Los Angeles; Keith Nuechterlein, University of California Los Angeles; Larry J. Seidman, Harvard Medical School
• Language: English
• Date: 2016-02-16
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016 Elsevier B.V. Published by Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.schres.2016.02.003
• Title of Journal or Parent Work: Schizophrenia Research
• Volume: 172
• Issue: 1-3
• Start Page: 106
• End Page: 113
• Grant/Funding Information: The Harvard Clinical and Translational Science Center Harvard Catalyst Clinical Research Center at Beth Israel Deaconess Medical Center, A Harvard University Clinical and Translational Science Center Research Unit (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award 1UL1 TR001102-01 financial contributions from Harvard University and its affiliated academic health care centers).; National Institute of Mental Health grants (U01MH0818902 to T.D.C., U01MH081984 to J.M.A., P50MH066286 to C.E.B., U01MH082022 to K.S.C., U01MH081857 to B.A.C., U01MH082004 to D.O.P., U01MH081928 to L.J.S., U01MH081988 to E.F.W., U01MH066160 to S.W.W., P50MH080272 to R.W. M.) and the Commonwealth Research Center of the Massachusetts Department of Mental Health (SCDMH82101008006 to L.J.S.).; This work was also conducted with support from Harvard Catalyst
• Keywords: schizophrenia; Psychosis; cognition; Adolescents; clinical high risk; MATRICS Consensus Cognitive Battery; Healthy Controls
• Research Categories: Psychology, Behavioral; Health Sciences, Mental Health

Abstract

The MATRICS Consensus Cognitive Battery (MCCB) fills a significant need for a standardized battery of cognitive tests to use in clinical trials for schizophrenia in adults aged 20–59. A need remains, however, to develop norms for younger individuals, who also show elevated risks for schizophrenia. Toward this end, we assessed performance in healthy adolescents. Baseline MCCB, reading and IQ data were obtained from healthy controls (ages 12–19) participating in two concurrent NIMH-funded studies: North American Prodromal Longitudinal Study phase 2 (NAPLS-2; n = 126) and Boston Center for Intervention Development and Applied Research (CIDAR; n = 13). All MCCB tests were administered except the Managing Emotions subtest from the Mayer–Salovey–Caruso Emotional Intelligence Test. Data were collected from 8 sites across North America. MCCB scores were presented in four 2-year age cohorts as T-scores for each test and cognitive domain, and analyzed for effects of age and sex. Due to IQ differences between age-grouped subsamples, IQ served as a covariate in analyses. Overall and sex-based raw scores for individual MCCB tests are presented for each age-based cohort. Adolescents generally showed improvement with age in most MCCB cognitive domains, with the clearest linear trends in Attention/Vigilance and Working Memory. These control data show that healthy adolescence is a dynamic period for cognitive development that is marked by substantial improvement in MCCB performance through the 12–19 age range. They also provide healthy comparison raw scores to facilitate clinical evaluations of adolescents, including those at risk for developing psychiatric disorders such as schizophrenia-related conditions.