Industrial toxicants and Parkinson's disease

• Type of Material: Article
• Authors: William Michael Caudle, Emory University; Thomas Guillot III, Emory University; Carlos R. Lazo, Emory University; Gary W Miller, Emory University
• Language: English
• Date: 2012-03
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.neuro.2012.01.010
• Title of Journal or Parent Work: NeuroToxicology
• ISSN: 0161-813X
• Volume: 33
• Issue: 2
• Start Page: 178
• End Page: 188
• Grant/Funding Information: This work was supported by grants from the National Institutes of Health 1P01ES016731, 5T32 ES 012870, 1P50NS071669, and 4R00ES017477.
• Research Categories: Health Sciences, Toxicology; Biology, Neuroscience

Abstract

The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson’s disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.