Treatment strategies of hospitalized patients with coronavirus disease-19 (vol 12, pg 11224, 2020)

• Type of Material: Article
• Authors: Yaxiong Huang, First Hospital of Changsha City; Chunlin Cai, First Hospital of Changsha City; Jinglei Zang, Changsha Health Vocational College; Jun Xie, First Hospital of Changsha City; Dan Xu, First Hospital of Changsha City; Fang Zheng, First Hospital of Changsha City; Tao Zhan, First Hospital of Changsha City; Kang Huang, First Hospital of Changsha City; Yikai Wang, Emory University; Xiao Wang, ICF, 3 Corporate Square NE; Zhe-Yu Hu, Central South University; Yapeng Deng, Central South University; Yuanlin Xie, First Hospital of Changsha City
• Language: English
• Date: 2021-04-30
• Publisher: Impact Journals LLC.
• Publication Version: Final Published Version
• Copyright Statement: © 2020 Huang et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.18632/aging.103370
• Title of Journal or Parent Work: Aging
• Volume: 13
• Issue: 8
• Start Page: 12294
• End Page: 12294
• Grant/Funding Information: Hunan Provincial Department of Science and Technology, Social Development Branch (2020SK3013, Yuanlin Xie; 2019SK20322, Zhe-Yu Hu).
• Keywords: Life Sciences & Biomedicine; Geriatrics & Gerontology; Science & Technology; Cell Biology
• Research Categories: Health Sciences, Oncology; Biology, Cell; Gerontology; Health Sciences, Public Health

Abstract

With the outbreak of coronavirus disease-19 (COVID-19), Changsha faced an increasing burden of treating the Wuhan migrants and their infected patients. This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020. Of 238 patients 43.7% visited Wuhan, 58.4% got in touch with Wuhan people, and 47.5% had contacted with diagnosed patients. 37.8% patients had family members infected. 190 cases had mild / general disease, and 48 cases had severe / critical disease. Compared to mild or general patients, more severe or critical patients visited Wuhan (59.6% vs 40.2%; P=0.02) and contacted with Wuhan people (74.5% vs 55.0%; P=0.02). All patients received antiviral treatment, including Lopinavir / Ritonavir (29.3%), Interferon (14.6%) and their combination (40.6%), Arbidol (6.7%), Xuebijing (7.1%) and Chloroquine phosphate (1.3%). Severe and critical patients received glucocorticoid, Gamma-globulin and oxygen inhalation. Some received mechanic ventilation support. As of 02/27, 161 patients discharged. The median length of hospital stay was 13 days. The 10-, 14-, 20- and 28-day discharge rate was 19.1%, 42.8%, 65.0% and 76.4%, respectively. No hospital-related transmission was observed.