Cardiac Lymphatic Insufficiency Leads to Diastolic Dysfunction Via Myocardial Morphologic Change

• Type of Material: Article
• Authors: Zhongyue Pu, Nagoya University; Yuuki Shimizu, Nagoya University; Takumi Hayashi, Nagoya University; Yiyang Che, Nagoya University; Junya Suzuki, Nagoya University; Kazuhito Tsuzuki, Nagoya University; Shingo Nartia, Nagoya University; rei Shibata, Nagoya University; John W Calvert, Emory University; Toyoaki Murohara, Nagoya University
• Language: English
• Date: 2023-04-12
• Publisher: Elsevier
• Publication Version: Final Published Version
• Copyright Statement: © 2023 The Authors
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1016%2Fj.jacbts.2023.01.008
• Title of Journal or Parent Work: JACC: basic Translational Science
• Volume: 8
• Issue: 8
• Start Page: 958
• End Page: 972
• Grant/Funding Information: This work was supported by Ministry of Education, Culture, Sports, Science and Technology of Japan grant 19K17519 (Dr Shimizu) and a Chukyo Longevity Medical and Promotion Foundation grant (Dr Shimizu.).
• Keywords: cardiac lymphatic vessels; hypertrophy; fibrosis; inflammation; cardiac distolic dysfunction
• Research Categories: Health Sciences, General

Abstract

Although cardiac lymphatic vessels have received increasing attention in recent years, there is still a knowledge gap between cardiac lymphatics and heart homeostasis in a normal heart. In the present study, we established a mouse model of cardiac lymphatic insufficiency ablating cardiac lymphatic collector vessels to reveal the crucial role of cardiac lymphatic vessels in maintaining cardiac homeostasis and the impact on cardiac function both in physiological and pathologic settings. Furthermore, therapeutic lymphangiogenesis improved the adverse effect on cardiac morphologic changes and functions. These findings suggest that the cardiac lymphatic system would be a novel therapeutic target for heart disease.