Exaggerated Eye Growth in IRBP-Deficient Mice in Early Development

• Type of Material: Article
• Authors: Jeffrey Wisard, Emory University; Amanda Faulkner, Atlanta VA Medical Center; Micah A. Chrenek, Emory University; Timothy Waxweiler, Emory University; Weston Waxweiler, Emory University; Christy Donmoyer, Allegheny College; Gregory I. Liou, Medical College of Georgia; Cheryl M. Craft, Keck School of Medicine of the University of Southern California and Doheny Eye Institute, Los Angeles, CA; Gregor F. Schmid, Atlanta VA Medical Center; Jeffrey Boatright, Emory University; Machelle Pardue, Emory University; John Nickerson, Emory University
• Language: English
• Date: 2011-07
• Publisher: Association for Research in Vision and Ophthalmology, Inc.
• Publication Version: Final Published Version
• Copyright Statement: © Association for Research in Vision and Ophthalmology
• Final Published Version (URL): http://dx.doi.org/10.1167%2Fiovs.10-7129
• Title of Journal or Parent Work: Investigative Ophthalmology & Visual Science
• Volume: 52
• Issue: 8
• Start Page: 5804
• End Page: 5811
• Grant/Funding Information: Supported by Research to Prevent Blindness; the Foundation Fighting Blindness; Fight for Sight; NEI Grants R01EY016470, R01EY014026 (JHB); R24EY017405, P30EY006360, R01EY016435 (MTP); DM102155 (GIL); R01EY015851 (CMC); P30EY003040 (DEI core); Mary D. Allen Chair in Vision Research, Doheny Eye Institute (CMC), and the Rehabilitation Research and Development Service, Department of Veterans Affairs.
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

In addition to its role in the visual cycle, IRBP is needed for normal eye development. Absence of IRBP results in excessive eye growth and profound myopic shift, a process that begins between P7 and P10. Distinct from this, the IRBP KO retina begins degenerating at P23.