Anti-Mullerian hormone levels in nurses working night shifts

• Type of Material: Article
• Authors: Candice Y. Johnson, Centers for Disease Control and Prevention; Lauren J. Tanz, Harvard T.H. Chan School of Public Health; Christina C. Lawson, Centers for Disease Control and Prevention; Penelope Howards, Emory University; Elizabeth R. Bertone-Johnson, University of Massachusetts; A. Heather Eliassen, Harvard T.H. Chan School of Public Health; Eva S. Schernhammer, Brigham & Womens Hospital; Janet W. Rich-Edwards, Harvard T.H. Chan School of Public Health
• Language: English
• Date: 2019-04-03
• Publisher: Routledge Journals, Taylor Francis Ltd.
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Taylor & Francis Group, LLC.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1080/19338244.2019.1577210
• Title of Journal or Parent Work: Archives of Environmental & Occupational Health
• Volume: 75
• Issue: 3
• Start Page: 136
• End Page: 143
• Grant/Funding Information: Funding for this work was provided by grants OH009803, R01CA67262, R01CA178949, R01HD078517, and UM1CA17626 from the National Institutes of Health and by contract number 200–2015-M-61780 to the Brigham and Women’s Hospital from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health.
• Keywords: Environmental Sciences; Polycystic ovary syndrom; Public, Environmental & Occupational Health; Nurses' Health Study; ovarian reserve; Anti-Mullerian hormone; Life Sciences & Biomedicine; Sub-fecundity; Age; Reserve; Menopause; nurses; Pregnancy; Time; Women; Science & Technology; shift work; Follicule stimulating hormone; Environmental Sciences & Ecology; Risk
• Research Categories: Health Sciences, Public Health; Health Sciences, Nursing; Health Sciences, Health Care Management; Health Sciences, Occupational Health and Safety

Abstract

Our objective was to examine associations between night shift work and serum anti-Müllerian hormone (AMH) levels. We analyzed 1,537 blood samples from premenopausal female nurses in the Nurses’ Health Study II, assayed for AMH. Rotating or permanent night shifts worked in the two weeks before blood collection and years of rotating night shift work were obtained via questionnaire. We found no associations between recent night shifts or rotating night shift work and AMH. The median difference in AMH was 0.3 (95% CI: -0.4, 0.8) ng/mL for ≥5 versus 0 recent night shifts and -0.1 (95% CI: -0.4, 0.3) ng/mL for ≥6 versus 0 years of rotating night shift work. Although we found no associations between night shift work and AMH, this does not preclude associations between night shift work and fertility operating through other mechanisms.