Publication

The potential role of magnetic resonance spectroscopy in image-guided radiotherapy

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Last modified
  • 03/05/2025
Type of Material
Authors
    Mai Lin Nguyen, Stanford UniversityBrooke Willows, University of ArizonaRihan Khan, University of ArizonaAlexander Chi, West Virginia UniversityLyndon Kim, Thomas Jefferson UniversitySherif Nour, Emory UniversityThomas Sroka, Dartmouth CollegeChristine Kerr, Centre Val d’AurelleJuan Godinez, Florida Radiation Oncology GroupMelissa Mills, University of ArizonaUlf Karlsson, Marshfield ClinicGabor Altdorfer, Camden Clark Medical CenterNam Phong Nguyen, Howard University HospitalGordon Jendrasiak, East Carolina University
Language
  • English
Date
  • 2014-05-05
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2014 Nguyen, Willows, Khan, Chi, Kim, Nour, Sroka, Kerr, Godinez, Mills, Karlsson, Altdorfer, Nguyen, Jendrasiak and The International Geriatric Radiotherapy Group.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2234-943X
Volume
  • 4 MAY
Start Page
  • 91
End Page
  • 91
Abstract
  • Magnetic resonance spectroscopy (MRS) is a non-invasive technique to detect metabolites within the normal and tumoral tissues. The ability of MRS to diagnose areas of high metabolic activity linked to tumor cell proliferation is particularly useful for radiotherapy treatment planning because of better gross tumor volume (GTV) delineation. The GTV may be targeted with higher radiation dose, potentially improving local control without excessive irradiation to the normal adjacent tissues. Prostate cancer and glioblastoma multiforme (GBM) are two tumor models that are associated with a heterogeneous tumor distribution. Preliminary studies suggest that the integration of MRS into radiotherapy planning for these tumors is feasible and safe. Image-guided radiotherapy (IGRT) by virtue of daily tumor imaging and steep dose gradient may allow for tumor dose escalation with the simultaneous integrated boost technique (SIB) and potentially decrease the complications rates in patients with GBM and prostate cancers.
Author Notes
  • Correspondence: Nam Phong Nguyen, Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue N.W., Washington DC 20060, USA e-mail: namphong.nguyen@yahoo.com
Keywords
Research Categories
  • Health Sciences, Oncology
  • Health Sciences, Radiology

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