Structure and recognition of polyubiquitin chains of different lengths and linkage

• Type of Material: Article
• Authors: David Fushman, University of Maryland; Keith D Wilkinson, Emory University
• Language: English
• Date: 2011-12-01
• Publisher: Faculty of 1000
• Publication Version: Final Published Version
• Copyright Statement: © 2011 Faculty of 1000 Ltd
• License: Creative Commons Attribution-Noncommercial 3.0 Unported
• Final Published Version (URL): http://f1000.com/reports/b/3/26
• Title of Journal or Parent Work: F1000 Biology Reports
• ISSN: 1757-594X
• Volume: 3
• Issue: 26
• Start Page: 1
• End Page: 10
• Research Categories: Biology, Genetics; Chemistry, Biochemistry

Abstract

The polyubiquitin signal is post-translationally attached to a large number of proteins, often directing formation of macromolecular complexes resulting in the translocation, assembly or degradation of the attached protein. Recent structural and functional studies reveal general mechanisms by which different architectures and length of the signal are distinguished.