Simian immunodeficiency virus macaque models of HIV latency

• Type of Material: Article
• Authors: Jesse D. Deere, University of California, Davis; Raymond Schinazi, Emory University; Thomas W. North, University of California, Davis
• Language: English
• Date: 2011-01-01
• Publisher: LIPPINCOTT WILLIAMS & WILKINS
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: 2011
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1097/COH.0b013e32834086ce
• Title of Journal or Parent Work: CURRENT OPINION IN HIV AND AIDS
• Volume: 6
• Issue: 1
• Start Page: 57
• End Page: 61
• Grant/Funding Information: This work was supported in part by NIH program project grant P01-AI058708 and NIH grant 1R01-RR-025996 (T.W.N. and R.F.S.). It was also supported by the Emory Centers for AIDS Research NIH grant 2P30-AI-050409 and the Department of Veterans Affairs.; J.D.D. was also supported in part by NIH training grant T32-AI60555.
• Keywords: ACTIVE ANTIRETROVIRAL THERAPY; Science & Technology; VIREMIA; CD4(+) T-CELLS; VIRAL RESERVOIRS; INFECTION; latency; Infectious Diseases; Life Sciences & Biomedicine; RHESUS MACAQUES; ANIMAL-MODEL; RESISTANCE; Immunology; nonhuman primate model of AIDS therapy; simian immunodeficiency virus; TYPE-1; viral persistence; RT-SHIV; REVERSE-TRANSCRIPTASE INHIBITORS
• Research Categories: Health Sciences, Immunology; Biology, Virology; Biology, Cell

Abstract

The macaque models of AIDS are well suited for addressing viral persistence during antiretroviral therapy, including viral latency, residual replication, and tissue organ distribution. © 2010 Wolters Kluwer Health