A report from the Leukemia Electronic Abstraction of Records Network on risk of hepatotoxicity during pediatric acute lymphoblastic leukemia treatment

• Type of Material: Article
• Authors: Joanna S. Yi, Baylor College of Medicine; Tiffany M. Chambers, Baylor College of Medicine; Kelly D. Getz, University of Pennsylvania Perelman School of Medicine; Tamara Miller, Emory University; Evanette Burrows, University of Pennsylvania Perelman School of Medicine; Marla H. Daves, Baylor College of Medicine; Philip J. Lupo, Baylor College of Medicine; Michael E. Scheurer, Baylor College of Medicine; Richard Aplenc, University of Pennsylvania Perelman School of Medicine; Karen R. Rabin, Baylor College of Medicine; Maria M. Gramatges, Baylor College of Medicine
• Language: English
• Date: 2022-05-01
• Publisher: Ferrata Storti Foundation
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Ferrata Storti Foundation
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3324/haematol.2021.279805
• Title of Journal or Parent Work: Haematologica
• Volume: 107
• Issue: 5
• Start Page: 1185
• End Page: 1188
• Grant/Funding Information: Alex’s Lemonade Stand Foundation (ALSF) Epidemiology Award (to RA), ALSF Young Investigator Award (to KDG), St. Baldrick’s Consortium Grant with generous support from the Micaela’s Army Foundation (to PJL, KRR, and MES), Cancer Prevention and Research Institute of Texas #RP160771 (to MES), National Institutes of Health (NIH) National Cancer Institute (5K12CA090433-17, Principal investigator: Dr. Susan Blaney, support for JSY and 1P20CA262733-01, Principal investigators: Lupo and Rabin), NIH National Heart, Lung, and Blood Institute Career Development Award 5K01HL143153 (to KDG), and NIH National Cancer Institute Career Development Award K07CA211956 (to TPM).
• Keywords: Humans; Electronics; Child; Chemical and Drug Induced Liver Injury; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Drug-Related Side Effects and Adverse Reactions
• Research Categories: Engineering, Electronics and Electrical; Health Sciences, Toxicology; Health Sciences, Oncology

Abstract

The objective of this work was to identify determinants of treatment-associated hepatotoxicity (TAH) in a diverse population of 782 children with acute lymphoblastic leukemia (ALL). Based on extracted electronic medical record data, nearly all subjects experienced mildly elevated hepatic laboratory values (HL), particularly those given high-intensity treatment. Furthermore, 15.9% of subjects experienced TAH in at least one postinduction treatment phase, which was associated with increased body mass index, but did not affect relapse-free survival.