Publication

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

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Last modified
  • 05/14/2025
Type of Material
Authors
    Diane G. Carnathan, Emory UniversityKirti Kaushik, La Jolla Institute for Allergy and ImmunologyAli H. Ellebedy, Emory UniversityChiamaka A. Enemuo, Emory UniversityEtse H. Gebru, Emory UniversityPallavi Dhadvai, Emory UniversityMohammed Ata Ur Rasheed, Emory UniversityMatthias G. Pauthner, Scripps Research InstituteGabriel Ozorowski, Scripps Research InstituteRafi Ahmed, Emory UniversityDennis R. Burton, Scripps Research InstituteAndrew B. Ward, Scripps Research InstituteGuido Silvestri, Emory UniversityShane Crotty, Scripps Research InstituteMichela Locci, Scripps Research Institute
Language
  • English
Date
  • 2020-06-16
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2020 Carnathan, Kaushik, Ellebedy, Enemuo, Gebru, Dhadvai, Rasheed, Pauthner, Ozorowski, Ahmed, Burton, Ward, Silvestri, Crotty and Locci.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 11
Start Page
  • 1213
End Page
  • 1213
Grant/Funding Information
  • This study was funded by NIH NIAD Grant No. R01AI123738 (ML), NIH NIAID Grant No. R01AI125068 (SC and GS), NIH NIAID 1UM1Al100663 to the Scripps CHAVI-ID (SC, RA, GS, AW, DB), NIH NIAID 1UM144462 to the Scripps CHAVD (SC, RA, GS, AW, DB), and National Primate Research Center funding (P51RR000165/OD011132) to the Yerkes National Primate Research Center.
Supplemental Material (URL)
Abstract
  • T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in manipulating TFH cell responses. Herein, we describe an HIV vaccine development approach exploiting the cytokine activin A to improve antibody responses against recombinant HIV Envelope (Env) trimers in non-human primates. Administration of activin A improved the magnitude of Env-specific antibodies over time and promoted a significant increase in Env-specific plasma cells in the bone marrow. The boost in antibody responses was associated with reduced frequencies of T follicular regulatory (TFR) cells and increased germinal center T follicular helper (GC-TFH) to TFR cell ratios. Overall, these findings suggest that adjuvants inducing activin A production could potentially be incorporated in future rational design vaccine strategies aimed at improving germinal centers, long-lived plasma cells, and sustained antibody responses.
Author Notes
Keywords
Research Categories
  • Biology, Microbiology
  • Health Sciences, Pathology
  • Health Sciences, Immunology
  • Biology, Cell

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