Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

• Type of Material: Article
• Authors: Bulent Yilmaz, Izmir Katip Celebi University; Priyathama Vellanki, Emory University; Baris Ata, Koc University; Bulent Okan Yildiz, Hacettepe University
• Language: English
• Date: 2018-02-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 American Society for Reproductive Medicine
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.fertnstert.2017.10.018
• Title of Journal or Parent Work: Fertility and Sterility
• ISSN: 0015-0282
• Volume: 109
• Issue: 2
• Start Page: 356
• End Page: +
• Keywords: first-degree relatives; FAMILY-HISTORY; Reproductive Biology; INSULIN-RESISTANCE; FIRST-DEGREE RELATIVES; SYNDROME PCOS; II DIABETES-MELLITUS; CARDIOVASCULAR RISK; IMPAIRED GLUCOSE-TOLERANCE; Life Sciences & Biomedicine; Obstetrics & Gynecology; Science & Technology; 1ST-DEGREE RELATIVES; polycystic ovary syndrome; 1ST DEGREE RELATIVES; hypertension; Dyslipidemia; DEHYDROEPIANDROSTERONE-SULFATE; metabolic syndrome
• Research Categories: Health Sciences, Obstetrics and Gynecology; Biology, Biostatistics

Abstract

Objective: To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Mothers, fathers, sisters, and brothers of women with and without PCOS. Intervention(s): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles. Main Outcome Measure(s): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Result(s): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls. Conclusion(s): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS. Systematic Review Registration Number: PROSPERO 2016 CRD42016048557.