Globus Pallidus Discharge Is Coincident with Striatal Activity during Global Slow Wave Activity in the Rat

• Type of Material: Article
• Authors: Joshua A. Goldberg, Emory University; Svetlana S. Kats, Emory University; Dieter Jaeger, Emory University
• Language: English
• Date: 2003-11-05
• Publisher: Society for Neuroscience
• Publication Version: Final Published Version
• Copyright Statement: © 2003 Society for Neuroscience
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): https://doi.org/10.1523/JNEUROSCI.23-31-10058.2003
• Title of Journal or Parent Work: The Journal of Neuroscience
• Volume: 23
• Issue: 31
• Start Page: 10058
• End Page: 10063
• Grant/Funding Agency: Yeshaya Horowitz Association; Emory University; National Institute of Neurological Disorders and Stroke; Michael J. Fox Foundation; Parkinson's Disease Foundation
• Grant/Funding Information: This work was supported by Grant RO1-NS39852 to D. J. by the National Institute of Neurological Disorders and Stroke and by the Michael J. Fox Foundation. J.A.G. was supported by a summer fellowship from the Parkinson's Disease Foundation and by the Yeshaya Horowitz Association. S.S.K. was supported by a summer undergraduate research program at Emory fellowship.
• Keywords: Parkinson's disease; bursting; subthalamic nucleus; synchrony; basal ganglia; inhibition
• Subject - Topics: Neurophysiology; Computational neuroscience; Neurosciences

Abstract

The emergence of bursting and oscillations in the basal ganglia under normal and pathological conditions has attracted considerable interest, but the neural substrate of these patterns is poorly understood. Here we use multisite recordings in anesthetized rats to examine the relationship of globus pallidus (GP) spiking and striatal activity in relation to cortical slow-wave activity. We found that GP neurons displayed increased spike rates or bursts coincident with cortical activation and striatal up states. Furthermore, the onset of GP bursts typically coincides with transitions to striatal up states that precede striatal spiking. These data indicate that GP activity is driven by excitatory corticosubthalamic input during periods of synchronized bursting activity.