Interplay effect of target motion and pencil-beam scanning in proton therapy for pediatric patients

• Type of Material: Article
• Authors: Andrew J. Boria, St. Jude Children's Research Hospital; Jinsoo Uh, St. Jude Children's Research Hospital; Fakhriddin Pirlepesov, St. Jude Children's Research Hospital; James C. Stuckey, St. Jude Children's Research Hospital; Marian Axente, Emory University; Melissa A. Gargone, St. Jude Children's Research Hospital; Chia-ho Hua, St. Jude Children's Research Hospital
• Language: English
• Date: 2019-09-01
• Publisher: Particle Therapy
• Publication Version: Final Published Version
• Copyright Statement: 2018 International Journal of Particle Therapy
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.14338/IJPT-17-00030.1
• Title of Journal or Parent Work: International Journal of Particle Therapy
• Volume: 5
• Issue: 2
• Start Page: 1
• End Page: 10
• Keywords: particle therapy; interplay effect; tumor motion; proton therapy; pediatric patients
• Research Categories: Health Sciences, Rehabilitation and Therapy; Health Sciences, Radiology; Health Sciences, Oncology

Abstract

Purpose: To investigate the effect of interplay between spot-scanning proton beams and respiration-induced tumor motion on internal target volume coverage for pediatric patients. Materials and Methods: Photon treatments for 10 children with representative tumor motions (1-13 mm superior-inferior) were replanned to simulate single-field uniform dose- optimized proton therapy. Static plans were designed by using average computed tomography (CT) data sets created from 4D CT data to obtain nominal dose distributions. The motion interplay effect was simulated by assigning each spot in the static plan delivery sequence to 1 of 10 respiratory-phase CTs, using the actual patient breathing trace and specifications of a synchrotron-based proton system. Dose distributions for individual phases were deformed onto the space of the average CT and summed to produce the accumulated dose distribution, whose dose-volume histogram was compared with the one from the static plan. Results: Tumor motion had minimal impact on the internal target volume hot spot (D2), which deviated by ,3% from the nominal values of the static plans. The cold spot (D98) was also minimally affected, except in 2 patients with diaphragmatic tumor motion exceeding 10mm. The impact on tumor coverage wasmore pronounced with respect to the V99 rather than the V95. Decreases of 10% to 49% in the V99 occurred in multiple patients for whomthe beampaths traversed the lung-diaphragminterface and were, therefore,more sensitive to respiration-induced changes in the water equivalent path length. Fractionation alone apparently did not mitigate the interplay effect beyond 6 fractions. Conclusion: The interplay effect is not a concern when delivering scanning proton beams to younger pediatric patients with tumors located in the retroperitoneal space and tumor motion of ,5 mm. Children and adolescents with diaphragmatic tumor motion exceeding 10 mm require special attention, because significant declines in target coverage and dose homogeneity were seen in simulated treatments of such patients.