Migration of dendritic leukocytes from cardiac allografts into host spleens: A novel pathway for initiation of rejection

• Type of Material: Article
• Authors: Christian Larsen, Emory University; Peter J. Morris, University of Oxford; Jonathan M. Austyn, University of Oxford
• Language: English
• Date: 1990-01-01
• Publisher: Rockefeller University Press
• Publication Version: Final Published Version
• Copyright Statement: ® The Rockefeller University Press -
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1084/jem.171.1.307
• Title of Journal or Parent Work: Journal of Experimental Medicine
• ISSN: 0022-1007
• Volume: 171
• Issue: 1
• Start Page: 307
• End Page: 314
• Keywords: Medicine, Research & Experimental; Immunology; Life Sciences & Biomedicine; Research & Experimental Medicine; Science & Technology
• Research Categories: Health Sciences, Immunology

Abstract

It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against gully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.