Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

• Type of Material: Article
• Authors: Sean R. Stowell, Emory University; Cheryl L. Maier, Emory University; Connie Arthur, Emory University; Nicole H. Smith, Emory University; Kathryn R. Girard-Pierce, Emory University; Richard Cummings, Emory University; James C Zimring, Puget Sound Blood Center Research Institute; Jeanne Hendrickson, Emory University
• Language: English
• Date: 2012-09-07
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2012 Sean R. Stowell et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://www.hindawi.com/journals/cdi/2012/307093/
• Title of Journal or Parent Work: Clinical And Developmental Immunology
• ISSN: 1740-2522
• Volume: 2012
• Issue: 2012
• Start Page: 1
• End Page: 12
• Research Categories: Health Sciences, Human Development; Health Sciences, Immunology

Abstract

Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.