Low startle magnitude may be a behavioral marker of vulnerability to cocaine addiction

• Type of Material: Article
• Authors: Marina G. Wheeler, Emory University; Erica Duncan, Emory University; Michael Davis, Emory University
• Language: English
• Date: 2017-01-01
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
• Final Published Version (URL): http://dx.doi.org/10.1002/syn.21943
• Title of Journal or Parent Work: Synapse
• ISSN: 0887-4476
• Volume: 71
• Issue: 1
• Start Page: 46
• End Page: 50
• Grant/Funding Information: This work was supported by the following NIH awards: 5T32DA015040-07 (M Kuhar), RO1DA018294 (ED), and MH47840 (MD).; The project was also funded in part by the NIH National Center for Research Resources P51RR000165, and the NIH Office of Research Infrastructure Programs / OD P51OD01132. This material is based upon work supported in part by the Department of Veterans Affairs: infrastructure support was provided to ED by the Veterans Affairs Merit Review Grant Program (1 I01 CX000974-01A1), the Mental Health, Research and Development, and Rehabilitation Research and Development Service Lines, and the Center for Visual and Neurocognitive Rehabilitation at the Atlanta Veterans Affairs Medical Center (ED).
• Keywords: Neurosciences & Neurology; cocaine; acoustic startle; Neurosciences; Life Sciences & Biomedicine; novelty preference; Science & Technology; AGONIST SKF 82958; PREPULSE INHIBITION; RETICULARIS PONTIS CAUDALIS; NUCLEUS; dopamine; PLACE PREFERENCE BEHAVIOR; DOPAMINE; RATS; DRUG-ADDICTION; REFLEX; self-administration; ACOUSTIC STARTLE
• Research Categories: Health Sciences, Rehabilitation and Therapy; Health Sciences, Medicine and Surgery

Abstract

Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Cocaine addicted men have low startle magnitude persisting during prolonged abstinence. Low startle rats show greater cocaine self-administration than high startle rats. Low startle may be a marker of a vulnerability to heightened cocaine-related behaviors in rats and similarly may be a marker of vulnerability to cocaine addiction in humans.