mSphere of Influence: Host Metabolism Is an Integral Part of the Immune Response to Infectious Diseases

• Type of Material: Article
• Authors: Jeffrey Collins, Emory University
• Language: English
• Date: 2021-07-01
• Publisher: AMER SOC MICROBIOLOGY
• Publication Version: Final Published Version
• Copyright Statement: © 2021 Collins.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1128/mSphere.00247-21
• Title of Journal or Parent Work: MSPHERE
• Volume: 6
• Issue: 4
• Start Page: 1
• End Page: 3
• Keywords: Life Sciences & Biomedicine; Microbiology; metabolic modeling; Science & Technology; inflammation; immunity
• Research Categories: Health Sciences, Immunology; Biology, Microbiology

Abstract

Jeff Collins is a physician scientist in the Division of Infectious Diseases at Emory University focused on using metabolomics and systems biology to better understand the pathophysiology of tuberculosis disease, identify new biomarkers, and elucidate targets for host-directed therapeutics. In this mSphere of Influence article, he reflects on how the paper “Succinate is an inflammatory signal that induces IL-1b through HIF-1a” by Tannahill et al. (G. M. Tannahill, A. M. Curtis, J. Adamik, E. M. Palsson-McDermott, et al., Nature 496:238–242, 2013, https://doi.org/10.1038/nature11986) influenced him by highlighting the intersection between metabolism and the host response to infectious diseases