Prolonged Detection of Zika Virus Nucleic Acid Among Symptomatic Pregnant Women: A Cohort Study

• Type of Material: Article
• Authors: Matthew J. Lozier, Centers for Disease Control and Prevention; Eli Rosenberg, Emory University; Kate Doyle, Centers for Disease Control and Prevention; Laura Adams, Centers for Disease Control and Prevention; Liore Klein, Caduceus Healthcare; Jorge Munoz-Jordan, Centers for Disease Control and Prevention; Luisa I. Alvarado, Ponce University; Tyler M. Sharp, Centers for Disease Control and Prevention; Gabriella Paz-Bailey, Emory University
• Language: English
• Date: 2018-08-15
• Publisher: OXFORD UNIV PRESS INC
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2018.
• License: Creative Commons Universal : Public Domain Dedication
• Final Published Version (URL): http://dx.doi.org/10.1093/cid/ciy209
• Title of Journal or Parent Work: CLINICAL INFECTIOUS DISEASES
• Volume: 67
• Issue: 4
• Start Page: 624
• End Page: 627
• Grant/Funding Information: This work was supported by the Centers for Disease Control and Prevention and the Center for AIDS Research at Emory University [NIH P30AI050409].
• Keywords: Immunology; BRAIN; Science & Technology; INFECTION; Infectious Diseases; Life Sciences & Biomedicine; RNA; Microbiology
• Research Categories: Health Sciences, Immunology; Biology, Microbiology

Abstract

A prospective cohort of women with reverse transcription polymerase chain reaction (RT-PCR) confirmed Zika virus infection aged 18-39 years in Puerto Rico found that pregnant women have about a 3-fold longer estimated median detection of Zika virus RNA in serum, which can increase definitive diagnosis of infection and facilitate timely and appropriate clinical management.