Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

• Type of Material: Article
• Authors: Constance H. Fung, Dept of Veterans Affairs Greater Los Angeles; Elizabeth Vaughan, Emory University; Alayne D Markland, Dept of Veterans Affairs Birmingham; Alison J. Huang, University of California San Francisco; Michael N. Mitchell, Dept of Veterans Affairs Greater Los Angeles; Donald Bliwise, Emory University; Sonia Ancoli-Israel, University of California San Diego; Susan Redline, Brigham and Women’s Hospital; Cathy A Alessi, Dept of Veterans Affairs Greater Los Angeles; Katie Stone, California Pacific Medical Center
• Language: English
• Date: 2017-11-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society
• Final Published Version (URL): http://dx.doi.org/10.1111/jgs.15027
• Title of Journal or Parent Work: Journal of the American Geriatrics Society
• ISSN: 0002-8614
• Volume: 65
• Issue: 11
• Start Page: 2502
• End Page: 2509
• Grant/Funding Information: Dr. Markland is supported by NIH funding through the National Institute on Diabetes and Digestive and Kidney Disease (1R211DK096201-01).; Dr. Vaughan is supported by a Rehabilitation R&D CDA-2 award from the Department of Veterans Affairs 1 IK2 RX000747-01.; Dr. Fung is supported by the National Institute On Aging of the National Institutes of Health under Award Number K23AG045937 and The Beeson Career Development in Aging Research Award Program (supported by NIA, AFAR, The John A. Hartford Foundation, and The Atlantic Philanthropies).; Funding sources: The Study of Osteoporotic Fractures (SOF) is supported by National Institutes of Health funding. The National Institute on Aging (NIA) provides support under the following grant numbers: R01 AG005407, R01 AR35582, R01 AR35583, R01 AR35584, R01 AG005394, R01 AG027574, R01 AG027576, and R01 AG026720.
• Keywords: sleep quality; ADULTS; octogenarians; GUIDELINE; HEALTH; DIAGNOSIS; Science & Technology; OF-LIFE; POPULATION; Gerontology; ACTIGRAPHY; SOCIETY; nonagenarians; Life Sciences & Biomedicine; Geriatrics & Gerontology; nocturia; CHRONIC INSOMNIA; OBJECTIVE SLEEP
• Research Categories: Health Sciences, Rehabilitation and Therapy

Abstract

Objectives 1) To examine relationships between frequency of nocturia and self-reported sleep quality and objective sleep measures in older women and 2) to estimate the amount of variation in sleep measures that is specifically attributable to frequency of nocturia. Design and Setting Secondary, cross sectional analysis of the multicenter prospective cohort Study of Osteoporotic Fractures (SOF) Participants Community-dwelling women aged ≥ 80 years Measurements Frequency of nocturia in the previous 12 months, Pittsburgh Sleep Quality Index sleep quality subscale, and actigraphy-measured wake after sleep onset (WASO) and total sleep time (TST). Results Of 1,520 participants, 25% (N=392) reported their nocturia frequency was 3–4 times/night and an additional 60% (N=917) reported their nocturia frequency was 1–2 times/night. More frequent nocturia was associated with poor sleep quality (3–4/night: 26.8% reported fairly bad or very bad sleep quality; 1–2/night: 14.7%; 0/night: 7.7%; p<.001) and longer WASO (3–4/night: 89.8 minutes; 1–2/night: 70.6; 0/night: 55.5; p<.001). In nested regression models, a nocturia frequency of 3–4/night quadrupled the odds of poor sleep quality (odds ratio: 4.26 [95% CI 1.65, 11.01]; p=.003) and was associated with a 37-minute worsening in WASO (95% CI 26.0, 49.0; p<.001). Frequency of nocturia explained an additional 6% variation in WASO, above and beyond demographic, medical/psychiatric conditions, and medication factors (ΔR2=.06). Conclusions Nocturia is common among octogenarian and nonagenarian women and is independently associated with poor sleep quality and longer wake time at night. Interventions that improve nocturia may be useful in improving sleep quality and wake time at night.