Burden of respiratory syncytial virus hospitalisation among infants born at 32-35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies

• Type of Material: Article
• Authors: M. Lanari, S. Orsola University Hospital; Evan Anderson, Emory University; M. Sheridan-Pereira, Trinity College Dublin; X. Carbonell-Estrany, Hospital Clinic Barcelona; B. Paes, McMaster University; B. S. Rodgers-Gray, Strategen Ltd; J. R. Fullarton, Strategen Ltd; E. Grubb, AbbVie Inc; M. Blanken, Universitair Medisch Centrum Utrecht
• Language: English
• Date: 2020-01-01
• Publisher: Cambridge University Press
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s), 2020. Published by Cambridge University Press.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1017/S0950268820001661
• Title of Journal or Parent Work: Epidemiology & Infection
• Volume: 148
• Start Page: e170
• End Page: e170
• Grant/Funding Information: Financial support for this study was provided by AbbVie. AbbVie participated in analysis and interpretation of data, drafting, reviewing and approving the publication.
• Keywords: Young children; RSV hospitalisation; Infectious Diseases; Respiratory syncytial virus; Mortality; Lower respiratory tract infection; Life Sciences & Biomedicine; Science & Technology; Epidemiology; Preterm infants; Infection; Risk factors; Completed weeks; Public, Environmental & Occupational Health; Respiratory support; Moderate-to-late preterm infants; Disease; Morbidity
• Research Categories: Health Sciences, Immunology; Health Sciences, Epidemiology; Engineering, Biomedical; Health Sciences, Health Care Management

Abstract

To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000-2014). Data from all 320-356 weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65 per 100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P = 0.032). Most RSVHs (60.1%) occurred in December-January. Median age at RSVH was 88 days (interquartile range (IQR): 54-159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2-6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2-5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3-7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2-8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3-8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3 vs. 4-6 days for 32-34 wGA; P < 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32-35 wGA infants are indicated.