Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals

• Type of Material: Article
• Authors: J. C. Lima-Junior, Fiocruz; T. M. Tran, Emory University; Esmeralda L. Meyer, Emory University; B. Singh, Emory University; S. G. De-Simone, Fiocruz; F. Santos, LACEN; C. T. Daniel-Ribeiro, Fiocruz; Alberto Moreno, Emory University; J. W. Barnwell, Centers for Disease Control and Prevention; Mary R Galinski, Emory University; J. Oliveira-Ferreira, Fiocruz
• Language: English
• Date: 2008-12-02
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.vaccine.2008.09.029
• Title of Journal or Parent Work: Vaccine
• ISSN: 0264-410X
• Volume: 26
• Issue: 51
• Start Page: 6645
• End Page: 6654
• Grant/Funding Information: This work was supported by Brazilian National Research Council – CNPq; Fiocruz; National Institute of Health, Grant RO1 AI0555994; and the Yerkes Regional Primate Research Center Base Grant.; Josue da Costa Lima Junior was the recipient of a CNPq Fellowship.
• Keywords: Science & Technology; Life Sciences & Biomedicine; SERUM ANTIBODIES; UNSTABLE MALARIA TRANSMISSION; BRAZILIAN AMAZON; DUFFY-BINDING-PROTEIN; FALCIPARUM; APICAL MEMBRANE ANTIGEN-1; Research & Experimental Medicine; Merozoite surface protein 9; Immunology; C-TERMINAL REGIONS; Medicine, Research & Experimental; Plasmodium vivax; T-CELLS; ANTIBODY-RESPONSE; Malaria; INFECTION; Vaccine
• Research Categories: Health Sciences, Immunology; Health Sciences, Medicine and Surgery; Biology, Entomology

Abstract

Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRII and PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-γ and IL-4 predominated in Ribeirinha, while IFN-γ predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.