Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

• Type of Material: Article
• Authors: Kunyan He, Emory University; Sung-Wuk Jang, Emory University; Jayashree Joshi, Emory University; Min-Heui Yoo, Emory University; Keqiang Ye, Emory University
• Language: English
• Date: 2011-06-01
• Publisher: The American Society for Cell Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2011 He et al.
• License: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1091%2Fmbc.E10-11-0923
• Title of Journal or Parent Work: Molecular Biology of the Cell
• Volume: 22
• Issue: 11
• Start Page: 1943
• End Page: 1954
• Grant/Funding Information: This work is supported by a grant from NIH (RO1, CA127119; NS-045627) to K. Ye.
• Research Categories: Health Sciences, Pathology

Abstract

UNC5B induces apoptosis in the absence of its cognate ligand netrins and acts as a tumor suppressor. UNC5B is a direct transcriptional target of p53 upon UV stimulation. Here we show that Akt phosphorylates PIKE-A and regulates its association with UNC5B and inhibits UNC5B-provoked apoptosis in a p53-dependent manner.