Publication

Editorial: Application of gene editing in neurodegenerative diseases, volume II

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Last modified
  • 06/25/2025
Type of Material
Authors
    Fangfang Qi, Sun Yat-Sen UniversityXingshun Xu, Soochow UniversityXing Guo, Nanjing Medical UniversityJunhong Luo, Jinan UniversityYujing Li, Emory UniversitySen Yan, Jinan University
Language
  • English
Date
  • 2023-10-31
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Qi, Xu, Guo, Luo, Li and Yan.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 17
Start Page
  • 1305302
Grant/Funding Information
  • This work was supported by the National Key Research and Development Program of China (2021YFA0805300) and National Natural Science of China (82271473, 82171244, and 81971021).
Abstract
  • Neurodegenerative disorders (NDs) are a broad category of ailments caused by progressive damage to cells and the nervous system that affect millions of individuals worldwide. The most prevalent neurodegenerative disorders include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Frontotemporal dementia (FTD), and Amyotrophic lateral sclerosis (ALS). The pathophysiology of NDs is known to be linked with gene mutations, including (1) presenilin (PSEN) and amyloid beta precursor protein (APP) mutations in AD; (2) mutations in PARK genes such as FBXO7, ATP13A2, SYNJ1, PLA2G6, DNAJC6, PINK1, and PRKN in PD, which participated in neuronal developmental processes; (3) mutant huntingtin gene (HTT) in HD; (4) TARDBP and Stmn2 in FTD; (5) mutations in C9orf72, superoxide dismutase (SOD1), TARDBP, Stmn2, and fused in sarcoma (FUS) gene in ALS, and so on.
Author Notes
Keywords
Research Categories
  • Biology, Molecular
  • Biology, Genetics
  • Biology, Neuroscience

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