A COVID Constellation: A Case of Transverse Myelitis and Acquired von Willebrand Syndrome

• Type of Material: Article
• Authors: Collins Mbonu, Emory University; Nneka Molokwu, Emory University; Alexander Matelski, Emory University
• Language: English
• Date: 2022-01-01
• Publisher: SAGE Publishing
• Publication Version: Final Published Version
• Copyright Statement: © 2022 American Federation for Medical Research
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1177/23247096221109205
• Title of Journal or Parent Work: Journal of Investigative Medicine High Impact Case Reports
• Volume: 10
• Start Page: 23247096221109205
• End Page: 23247096221109205
• Grant/Funding Information: The author(s) received no financial support for the research, authorship, and/or publication of this article.
• Keywords: COVID-19; von Willebrand disease; SARS-CoV-2; von Willebrand factor; Myelitis, Transverse; transverse myelitis; Humans; von Willebrand Factor; von Willebrand Diseases; acquired von Willebrand syndrome
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

The coronavirus disease 2019 (COVID-19) pandemic revealed a myriad of postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequelae, many of which remain poorly understood. We describe a rare presentation of a patient developing 2 simultaneous COVID-19 sequelae: transverse myelitis and acquired von Willebrand syndrome (AVWS). There have been numerous published case reports of patients developing transverse myelitis after a diagnosis of COVID-19. However, none have described AVWS as an observed complication from SARS-CoV-2 infection. To our knowledge, this case report is the first to describe AVWS as a result of COVID-19 infection, suggesting that patients with a prior diagnosis of COVID-19 are susceptible to developing this rare bleeding disorder.