Group B streptococcus infections of soft tissue and bone in California adults, 1995-2012

• Type of Material: Article
• Authors: EM Smith, California Emerging Infections Program; Mohammed Khan, Emory University; A Reingold, California Emerging Infections Program; JP Watt, California Emerging Infections Program
• Language: English
• Date: 2015-11-01
• Publisher: CAMBRIDGE UNIV PRESS
• Publication Version: Final Published Version
• Copyright Statement: © Cambridge University Press 2015
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1017/S0950268815000606
• Title of Journal or Parent Work: EPIDEMIOLOGY AND INFECTION
• Volume: 143
• Issue: 15
• Start Page: 3343
• End Page: 3350
• Grant/Funding Information: This work was supported by CDC Cooperative Agreement no. 5U50CK000201–02.
• Keywords: ARTHRITIS; DISEASE; Public, Environmental & Occupational Health; MANAGEMENT; EPIDEMIOLOGY; Infectious Diseases; epidemiology; Bone infections; UNITED-STATES; DIAGNOSIS; skin infections; Science & Technology; SKIN; Life Sciences & Biomedicine; PRACTICE GUIDELINES; streptococcal infections; NONPREGNANT ADULTS; joint infection
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Epidemiology

Abstract

Group B streptococcus (GBS) is an increasing cause of disease in adults. We present long-term trends in incidence of overall infections and identify characteristics of patients with GBS cellulitis, bone and joint infections. Active, population-based surveillance was conducted from 1995-2012 in three California counties and the data were analysed retrospectively. All cases had isolation of GBS from a normally sterile site. Cases of cellulitis were classified based on clinical diagnosis. GBS bone or joint infection was defined as isolation of GBS from a bone or joint or a diagnosis of osteomyelitis or septic arthritis. Medical charts were reviewed for demographic and clinical information. There were 3917 cases of GBS; the incidence of disease increased from 5·8 to 8·3 cases/100 000 persons (P < 0·001) from 1995 to 2012. In adults aged ≥40 years, the overall incidence of GBS increased from 8·5 to 14·2 cases/100 000 (P < 0·001) persons during the study period. The incidence of cellulitis increased from 1·6 to 3·8 cases/100 000 (P < 0·001), bone infection increased from 0·7 to 2·6 cases/100 000 (P < 0·001), and the incidence of joint infection remained approximately constant at an average rate of 1·0 case/100 000. The highest incidence rates were observed in men, persons aged ≥80 years, non-Hispanic blacks and Hispanics. Diabetes was the most common underlying condition (51·2% cellulitis cases, 76·3% bone infections, 29·8% joint infections).