Ambient Air Pollution and Birth Weight in Full-Term Infants in Atlanta, 1994–2004

• Type of Material: Article
• Authors: Lyndsey Darrow, Emory University; Matthew J Strickland, Emory University; Mitchel Klein, Emory University; James A. Mulholland, Georgia Institute of Technology; Paige Tolbert, Emory University
• Language: English
• Date: 2010-12-14
• Publisher: National Institute of Environmental Health Sciences (NIEHS)
• Publication Version: Final Published Version
• Copyright Statement: Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely.
• Final Published Version (URL): http://ehp.niehs.nih.gov/1002785/
• Title of Journal or Parent Work: Environmental Health Perspectives
• ISSN: 0091-6765
• Volume: 119
• Issue: 5
• Start Page: 731
• End Page: 737
• Grant/Funding Information: This work was supported by the National Institute of Environmental Health Sciences (NIEHS; R01-ES-012967-02S2A1) and the U.S. Environmental Protection Agency (EPA) Science to Achieve Results (STAR) fellowship program (FP-91655101-0).
• Keywords: birth weight; air pollution; pregnancy outcomes; particulate matter; air pollution epidemiology
• Research Categories: Environmental Sciences; Health Sciences, Public Health

Abstract

Background An emerging body of evidence suggests that ambient levels of air pollution during pregnancy are associated with fetal growth. Objectives We examined relationships between birth weight and temporal variation in ambient levels of carbon monoxide, nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone, particulate matter ≤ 10 μm in diameter (PM10), ≤ 2.5 μm (PM2.5), 2.5 to 10 μm (PM2.5–10), and PM2.5 chemical component measurements for 406,627 full-term births occurring between 1994 and 2004 in five central counties of metropolitan Atlanta. Methods We assessed relationships between birth weight and pollutant concentrations during each infant’s first month of gestation and third trimester, as well as in each month of pregnancy using distributed lag models. We also conducted capture-area analyses limited to mothers residing within 4 miles (6.4 km) of each air quality monitoring station. Results In the five-county analysis, ambient levels of NO2, SO2, PM2.5 elemental carbon, and PM2.5 water-soluble metals during the third trimester were significantly associated with small reductions in birth weight (−4 to −16 g per interquartile range increase in pollutant concentrations). Third-trimester estimates were generally higher in Hispanic and non-Hispanic black infants relative to non-Hispanic white infants. Distributed lag models were also suggestive of associations between air pollutant concentrations in late pregnancy and reduced birth weight. The capture-area analyses provided little support for the associations observed in the five-county analysis. Conclusions Results provide some support for an effect of ambient air pollution in late pregnancy on birth weight in full-term infants.