Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli

• Type of Material: Article
• Authors: Nazia Kamal, Emory University; William M Shafer, Emory University
• Language: English
• Date: 2010-01
• Publisher: American Society for Microbiology (ASM)
• Publication Version: Final Published Version
• Copyright Statement: © 2010, American Society for Microbiology
• Final Published Version (URL): http://aac.asm.org/content/54/1/506
• Title of Journal or Parent Work: Antimicrobial Agents and Chemotherapy
• Volume: 54
• Issue: 1
• Start Page: 506
• End Page: 508
• Grant/Funding Information: This work was supported by NIH grants AI 021150 and AI 062755 (both to W.M.S.) and a VA Merit Review grant (to W.M.S.). W.M.S. is the recipient of a Senior Research Career Scientist Award from VA Medical Research Service.
• Research Categories: Biology, Microbiology

Abstract

Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of α-hemolysis and antimicrobial resistance known to involve efflux pumps.